Technical details of permanent failure:
TEMP_FAILURE: SMTP Error (state 12): 421-: (RLY:CS4)
421 SERVICE NOT AVAILABLE
Here’s the explanation from the above URL:
This error message indicates that your email has been identified as coming from a server or web site that may have a compromised script or program available.
Please contact the server administrator or hosting provider for additional assistance.
Providers: This error message will allow the offending emails to stay in your mail queue. This will give you the opportunity to look at the offending mail, which should assist you in tracking down the compromised script.